Hepatocyte TRAF3 promotes insulin resistance and type 2 diabetes in mice with obesity
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چکیده
منابع مشابه
Type 2 diabetes mellitus in childhood: obesity and insulin resistance.
As rates of childhood obesity climb, type 2 diabetes mellitus has increasingly been diagnosed in children and adolescents, with the highest incidence occurring among youth from racial and ethnic minority backgrounds. The serious complications associated with type 2 diabetes mellitus make it essential for physicians to be aware of risk factors and screening guidelines, allowing for earlier patie...
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Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, insulin resistance and a systemic pro-inflammatory response. Here we show that tumour necrosis factor receptor-associated factor 3 (TRAF3) is upregulated in mouse and human livers with hepatic steatosis. After 24 weeks on a high-fat diet (HFD), obesity, insulin resistance, hepatic steatosis and inflammatory respons...
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The increase in obesity in the U.S. and elsewhere can be explained by a variety of factors, as outlined by David Allison and his colleagues. Not only is the fast food diet a factor, but also are changes in ambient temperature, obesity-causing psychoactive molecules, associative sorting, changes in smoking habits, and reduction in sleep. In particular is the increase in visceral fat, which is as...
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Myeloid cells, particularly macrophages, mediate metabolic inflammation, thus promoting insulin resistance and metabolic disease progression in obesity. Numerous cytokines, toxic metabolites, damage-associated molecular patterns, and pathogen-associated molecular patterns are involved in activating macrophages via their cognate receptors in obesity. TRAF3 (TNF receptor-associated factor 3) is a...
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Introduction: Progranulin (PGRN) has been recently introduced as a new indicator of chronic inflammatory response in type 2 diabetes. The present study aimed to investigate the effect of combined training on serum levels of progranulin, glycosylated hemoglobin (HbA1c), and insulin resistance in overweight and obese women with type 2 diabetes. Materials and Methods: A total of 36 women were divi...
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ژورنال
عنوان ژورنال: Molecular Metabolism
سال: 2015
ISSN: 2212-8778
DOI: 10.1016/j.molmet.2015.09.013